Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults.
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ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC9450828 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
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Derivation and validation of an epigenetic frailty risk score in population-based cohorts of older adults.
Li Xiangwei X Delerue Thomas T Schöttker Ben B Holleczek Bernd B Grill Eva E Peters Annette A Waldenberger Melanie M Thorand Barbara B Brenner Hermann H
Nature communications 20220907 1
DNA methylation (DNAm) patterns in peripheral blood have been shown to be associated with aging related health outcomes. We perform an epigenome-wide screening to identify CpGs related to frailty, defined by a frailty index (FI), in a large population-based cohort of older adults from Germany, the ESTHER study. Sixty-five CpGs are identified as frailty related methylation loci. Using LASSO regression, 20 CpGs are selected to derive a DNAm based algorithm for predicting frailty, the epigenetic fr ...[more]
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