Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality.
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ABSTRACT:
SUBMITTER: Rocco JM
PROVIDER: S-EPMC9452087 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
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Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality.
Rocco Joseph M JM Laghetti Paola P Di Stefano Mariantonietta M Sereti Irini I Ortega-Villa Ana A Wang Jing J Rupert Adam A Chironna Maria M Ye Lara L Liu Xiangdong X Anderson Megan V MV Burbelo Peter B PB Fiore Jose Ramon JR Saracino Annalisa A Lisco Andrea A
Open forum infectious diseases 20220820 9
In this study, abnormal levels of myeloid activation, endothelial damage, and innate immune markers were associated with severe coronavirus disease 2019 (COVID-19), while higher levels of metabolic biomarkers (irisin, leptin) demonstrated a protective effect. These data support a model for COVID-19 immunopathogenesis linking robust inflammation and endothelial damage in metabolically predisposed individuals. ...[more]
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