Molecular Changes in Relation to Alcohol Consumption and Hepatocellular Carcinoma.
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ABSTRACT:
SUBMITTER: Sasaki-Tanaka R
PROVIDER: S-EPMC9456124 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Publications
Molecular Changes in Relation to Alcohol Consumption and Hepatocellular Carcinoma.
Sasaki-Tanaka Reina R Ray Ranjit R Moriyama Mitsuhiko M Ray Ratna B RB Kanda Tatsuo T Kanda Tatsuo T
International journal of molecular sciences 20220826 17
Alcohol is the one of the major causes of liver diseases and promotes liver cirrhosis and hepatocellular carcinoma (HCC). In hepatocytes, alcohol is converted to acetaldehyde, which causes hepatic steatosis, cellular apoptosis, endoplasmic reticulum stress, peroxidation, production of cytokines and reduces immune surveillance. Endotoxin and lipopolysaccharide produced from intestinal bacteria also enhance the production of cytokines. The development of hepatic fibrosis and the occurrence of HCC ...[more]
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2013-10-28 | E-GEOD-51730 | biostudies-arrayexpress
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