Ontology highlight
ABSTRACT:
SUBMITTER: Guitton R
PROVIDER: S-EPMC9458446 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Guitton Romain R Nido Gonzalo S GS Tzoulis Charalampos C
Nucleic acids research 20220901 16
While most research suggests mitochondrial DNA (mtDNA) harbors low or no methylation, a few studies claim to report evidence of high-level methylation in the mtDNA. The reasons behind these contradictory results are likely to be methodological but remain largely unexplored. Here, we critically reanalyzed a recent study by Patil et al. (2019) reporting extensive methylation in human mtDNA in a non-CpG context. Our analyses refute the original findings and show that these do not reflect the biolog ...[more]