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Circ-TRIO promotes TNBC progression by regulating the miR-432-5p/CCDC58 axis.


ABSTRACT: Numerous studies have shown that circRNAs are aberrantly expressed in various cancers and play a significant role in tumor progression. However, the molecular mechanisms of circRNAs in triple-negative breast cancer (TNBC) remain ambiguous. By intersecting throughput data and qRT-PCR results from tissues and cell lines, circ-TRIO was identified as a potential oncogenic regulator of TNBC. Moreover, circ-TRIO expression was detected in TNBC tissues and was correlated with the recurrence and prognosis of TNBC patients. The circular characteristics of circ-TRIO were verified by RNase R and CHX assays. Functionally, the knockdown of circ-TRIO inhibited the proliferation, migration and invasion of TNBC cells, while the overexpression of circ-TRIO resulted in the opposite impacts. Mechanistically, a dual luciferase reporter assay and RNA immunoprecipitation were performed and indicated that circ-TRIO could combine with miR-432-5p to regulate the expression of coiled-coil domain containing 58 (CCDC58). In summary, our study illustrates that circ-TRIO plays an important role in the progression of TNBC by regulating the miR-432-5p/CCDC58 axis, which could broaden our insight into the underlying mechanisms and provide a novel prognostic marker of TNBC in the clinic.

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9458743 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Circ-TRIO promotes TNBC progression by regulating the miR-432-5p/CCDC58 axis.

Wang Zekun Z   Li Yaming Y   Yang Jingwen J   Liang Yiran Y   Wang Xiaolong X   Zhang Ning N   Kong Xiaoli X   Chen Bing B   Wang Lijuan L   Zhao Wenjing W   Yang Qifeng Q  

Cell death & disease 20220908 9


Numerous studies have shown that circRNAs are aberrantly expressed in various cancers and play a significant role in tumor progression. However, the molecular mechanisms of circRNAs in triple-negative breast cancer (TNBC) remain ambiguous. By intersecting throughput data and qRT-PCR results from tissues and cell lines, circ-TRIO was identified as a potential oncogenic regulator of TNBC. Moreover, circ-TRIO expression was detected in TNBC tissues and was correlated with the recurrence and prognos  ...[more]

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