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Advances in the study of HLA class Ib in maternal-fetal immune tolerance.


ABSTRACT: The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechanism of HLA-G have deepened and gradually explored the mechanism of HLA-E and HLA-F, which are also HLA class Ib molecules. In the maternal-fetal interface, trophoblast cells express HLA class Ib molecules to protect the fetus from maternal immune cells by binding to inhibitory receptors of decidual immune cells (DICs) and shifting Th1/Th2 balance toward Th2 bias. Further studies on the molecular mechanism of HLA class Ib molecules provide a reference for its application in the field of clinical assisted reproduction.

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9465335 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Advances in the study of HLA class Ib in maternal-fetal immune tolerance.

Yang Yiran Y   Wang Wanning W   Weng Jing J   Li Huifang H   Ma Yanmin Y   Liu Lingyan L   Ma Wei W  

Frontiers in immunology 20220829


The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechanism of HLA-G have deepened and gradually explored the mechanism of HLA-E and HLA-F, which are also HLA class Ib molecules. In the maternal-fetal interface, trophoblast cells express HLA class Ib molec  ...[more]

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