Basal ganglia engagement during REM sleep movements in Parkinson's disease.
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ABSTRACT:
SUBMITTER: Verma AK
PROVIDER: S-EPMC9468156 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Publications
Basal ganglia engagement during REM sleep movements in Parkinson's disease.
Verma Ajay K AK Acosta Lenis Sergio Francisco SF Aman Joshua E JE Sanabria David Escobar DE Wang Jing J Pearson Amy A Hill Meghan M Patriat Remi R Schrock Lauren E LE Cooper Scott E SE Park Michael C MC Harel Noam N Howell Michael J MJ MacKinnon Colum D CD Vitek Jerrold L JL Johnson Luke A LA
NPJ Parkinson's disease 20220912 1
To elucidate the role of the basal ganglia during REM sleep movements in Parkinson's disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13-35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150-350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep ...[more]
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