Ontology highlight
ABSTRACT:
SUBMITTER: Uddin MDM
PROVIDER: S-EPMC9468335 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Uddin M D Mesbah MDM Nguyen Ngoc Quynh H NQH Yu Bing B Brody Jennifer A JA Pampana Akhil A Nakao Tetsushi T Fornage Myriam M Bressler Jan J Sotoodehnia Nona N Weinstock Joshua S JS Honigberg Michael C MC Nachun Daniel D Bhattacharya Romit R Griffin Gabriel K GK Chander Varuna V Gibbs Richard A RA Rotter Jerome I JI Liu Chunyu C Baccarelli Andrea A AA Chasman Daniel I DI Whitsel Eric A EA Kiel Douglas P DP Murabito Joanne M JM Boerwinkle Eric E Ebert Benjamin L BL Jaiswal Siddhartha S Floyd James S JS Bick Alexander G AG Ballantyne Christie M CM Psaty Bruce M BM Natarajan Pradeep P Conneely Karen N KN
Nature communications 20220912 1
Age-related changes to the genome-wide DNA methylation (DNAm) pattern observed in blood are well-documented. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-related acquisition and expansion of leukemogenic mutations in hematopoietic stem cells (HSCs), is associated with blood cancer and coronary artery disease (CAD). Epigenetic regulators DNMT3A and TET2 are the two most frequently mutated CHIP genes. Here, we present results from an epigenome-wide association s ...[more]