Advanced strategies to thwart foreign body response to implantable devices.
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ABSTRACT:
SUBMITTER: Capuani S
PROVIDER: S-EPMC9472022 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Publications
Advanced strategies to thwart foreign body response to implantable devices.
Capuani Simone S Malgir Gulsah G Chua Corrine Ying Xuan CYX Grattoni Alessandro A
Bioengineering & translational medicine 20220302 3
Mitigating the foreign body response (FBR) to implantable medical devices (IMDs) is critical for successful long-term clinical deployment. The FBR is an inevitable immunological reaction to IMDs, resulting in inflammation and subsequent fibrotic encapsulation. Excessive fibrosis may impair IMDs function, eventually necessitating retrieval or replacement for continued therapy. Therefore, understanding the implant design parameters and their degree of influence on FBR is pivotal to effective and l ...[more]
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