Ontology highlight
ABSTRACT:
SUBMITTER: Walker JR
PROVIDER: S-EPMC94745 | biostudies-literature | 2000 Nov
REPOSITORIES: biostudies-literature
Walker J R JR Hervas C C Ross J D JD Blinkova A A Walbridge M J MJ Pumarega E J EJ Park M O MO Neely H R HR
Journal of bacteriology 20001101 21
The Escherichia coli DNA polymerase III tau and gamma subunits are single-strand DNA-dependent ATPases (the latter requires the delta and delta' subunits for significant ATPase activity) involved in loading processivity clamp beta. They are homologous to clamp-loading proteins of many organisms from phages to humans. Alignment of 27 prokaryotic tau/gamma homologs and 1 eukaryotic tau/gamma homolog has refined the sequences of nine previously defined identity and functional motifs. Mutational ana ...[more]