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Pulse Oximetry and Race in Critically Ill Adults.


ABSTRACT: For critically ill adults, oxygen saturation is continuously monitored using pulse oximetry (Spo2) as a surrogate for arterial oxygen saturation (Sao2). Skin pigmentation may affect accuracy of Spo2 by introducing error from statistical bias, variance, or both. We evaluated relationships between race, Spo2, Sao2, and hypoxemia (Sao2 < 88%) or hyperoxemia (Pao2 > 150 mm Hg) among adults receiving mechanical ventilation in a medical ICU.

Design

Single-center, observational study.

Setting

Medical ICU at an academic medical center.

Patients

Critically ill adults receiving mechanical ventilation from July 2018 to February 2021, excluding patients with COVID-19, with race documented as Black or White in the electronic medical record, who had a pair of Spo2 and Sao2 measurements collected within 10 minutes of each other.

Interventions

None.

Measurements

We included 1,024 patients with 5,557 paired measurements within 10 minutes, of which 3,885 (70%) were within 1 minute. Of all pairs, 769 (14%) were from Black patients and 4,788 (86%) were from White patients. In analyses using a mixed-effects model, we found that across the range of Spo2 values of 92-98%, the associated Sao2 value was approximately 1% point lower for Black patients compared with White patients. Among patients with a Spo2 value between 92% and 96%, Black patients were more likely to have both hypoxemia (3.5% vs 1.1%; p = 0.002) and hyperoxemia (4.7% vs 2.4%; p = 0.03), compared with White patients.

Conclusions

Among patients with a measured Spo2 of 92-96%, greater variation in Sao2 values at a given Spo2 resulted in a higher occurence rate of both hypoxemia and hyperoxemia for Black patients compared with White patients.

SUBMITTER: Seitz KP 

PROVIDER: S-EPMC9478292 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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For critically ill adults, oxygen saturation is continuously monitored using pulse oximetry (Spo<sub>2</sub>) as a surrogate for arterial oxygen saturation (Sao<sub>2</sub>). Skin pigmentation may affect accuracy of Spo<sub>2</sub> by introducing error from statistical bias, variance, or both. We evaluated relationships between race, Spo<sub>2</sub>, Sao<sub>2</sub>, and hypoxemia (Sao<sub>2</sub> < 88%) or hyperoxemia (Pao<sub>2</sub> > 150 mm Hg) among adults receiving mechanical ventilation i  ...[more]

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