Ontology highlight
ABSTRACT:
SUBMITTER: Kim SJ
PROVIDER: S-EPMC9478674 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Kim Soo Ji SJ Chi Chris C Pattanayak Gopal G Dinner Aaron R AR Rust Michael J MJ
Proceedings of the National Academy of Sciences of the United States of America 20220906 37
The cyanobacterial clock presents a unique opportunity to understand the biochemical basis of circadian rhythms. The core oscillator, composed of the KaiA, KaiB, and KaiC proteins, has been extensively studied, but a complete picture of its connection to the physiology of the cell is lacking. To identify previously unknown components of the clock, we used KaiB locked in its active fold as bait in an immunoprecipitation/mass spectrometry approach. We found that the most abundant interactor, other ...[more]