Dataset Information

Dermoscopic Findings of Discoid Lupus Erythematosus Involving the Eyelids.

ABSTRACT:

Introduction

Although facial involvement in discoid lupus erythematosus (DLE) is common, eyelid involvement is atypical. Identifying this condition is challenging due to misdiagnosis, and it is essential to avoid potential deformities of the eyelid margin.

Case presentation

We, herein, report the dermoscopic findings in 2 female patients with a confirmed diagnosis of DLE who presented eyelids involvement.

Discussion/conclusion

This study highlights the importance of performing a dermoscopy examination to help physicians obtain an early diagnosis of DLE.

SUBMITTER: Cortez de Almeida RF

PROVIDER: S-EPMC9485923 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

Dermoscopic Findings of Discoid Lupus Erythematosus Involving the Eyelids.

Cortez de Almeida Rita Fernanda RF Ferreira Bianca de Franco Marques BFM Melo Daniel Fernandes DF Benez Marcela M Vincenzi Colombina C Starace Michela M Tosti Antonella A

Skin appendage disorders 20220425 5

<h4>Introduction</h4>Although facial involvement in discoid lupus erythematosus (DLE) is common, eyelid involvement is atypical. Identifying this condition is challenging due to misdiagnosis, and it is essential to avoid potential deformities of the eyelid margin.<h4>Case presentation</h4>We, herein, report the dermoscopic findings in 2 female patients with a confirmed diagnosis of DLE who presented eyelids involvement.<h4>Discussion/conclusion</h4>This study highlights the importance of perform ...[more]

PMID: 36161083

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Project description:ImportanceClassification criteria are the standardized definitions that are used to enroll uniform cohorts for research studies. They emphasize high specificity and are distinct from diagnostic criteria. No universally recognized classification criteria currently exist for discoid lupus erythematosus (DLE), which has led to problematic heterogeneity in observational and interventional clinical studies across the field.ObjectiveTo create and validate classification criteria for DLE using 12 previously defined candidate criteria items.Design, setting, and participantsFor this diagnostic study, candidate criteria items were prospectively applied by dermatologists and dermatopathologists at clinical visits of patients with DLE or a condition that could be confused for DLE, termed a DLE mimicker, at academic dermatology practices across the United States, Poland, Japan, and South Korea. Data were collected from December 1, 2017, to February 1, 2019, and analyzed from March 1 to September 19, 2019.Main outcomes and measuresClinical features among these 2 groups were calculated and compared with χ2 or Fisher exact tests. Candidate models were identified using best subsets logistic regression analysis. Improvement tests, fit statistics, and discrimination were considered to choose a final model.ResultsNine sites contributed 215 patients, 15 of whom had missing or incomplete data. The final model for DLE classification criteria includes only clinical variables: atrophic scarring (3 points), location in the conchal bowl (2 points), preference for the head and neck (2 points), dyspigmentation (1 point), follicular hyperkeratosis and/or plugging (1 point), and erythematous to violaceous in color (1 point), with an area under the receiving operating characteristic curve of 0.91 (95% CI, 0.87-0.95). A score of at least 5 points yields a sensitivity of 84.1% and a specificity of 75.9% in the classification of DLE, with increasing scores yielding higher specificity.Conclusions and relevanceThese findings provide the initial validation of classification criteria for DLE for use in observational and clinical trials.

Dataset Information

Dermoscopic Findings of Discoid Lupus Erythematosus Involving the Eyelids.

Introduction

Case presentation

Discussion/conclusion

Publications

Dermoscopic Findings of Discoid Lupus Erythematosus Involving the Eyelids.

Similar Datasets

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