Dataset Information

Biologics for psoriasis patients under 18 years of age: Real-world evidence from the Chinese psoriasis real world evidence research group.

ABSTRACT:

Background

Treatment for pediatric psoriasis is challenging because of the lack of real-world evidence, especially for biological therapies.

Objectives

This study evaluated the efficacy and safety of biologics in children with psoriasis based on real-world evidence.

Methods

Pediatric psoriasis patients aged <18 years who were treated with biologics in our hospital (2020-2022) were prospectively analyzed. Patients treated with adalimumab, secukinumab, or ixekizumab were followed up for at least 16 weeks, and 22 of 38 patients completed the 52-week observation period. Dermatologist raters were blinded to ensure the reliability of the PASI, BSA, and PGA score assessments. PASI 75 or PGA 0/1 at week 12 represented an efficient indicator.

Results

Thirty-eight patients (20 males and 18 females; median age, 12.6 ± 4.1 years) were enrolled, and none were lost to follow-up. All participants were diagnosed with psoriasis, including plaque psoriasis (n = 36), nail psoriasis (n = 1), and pustular psoriasis (n = 1). Within 12 weeks, all patients achieved scores above PASI 75 and PGA 0/1. The average time to reach PASI 75 was 4.3 ± 2.0, 3.2 ± 1.8, and 2.4 ± 0.4 weeks in patients using adalimumab, secukinumab, and ixekizumab, respectively, and, 27.2% (3/11), 86.4% (19/22), and 75.0% (3/4) of these patients achieved PASI 100 at week 12, respectively. Moreover, 18 of 20 patients with plaque psoriasis maintained ≥PASI 75 after 52 weeks. The most commonly reported adverse effect was upper respiratory tract infection, and no severe adverse effects were reported.

Conclusions

Our real-world data demonstrated the safety and effectiveness of adalimumab, secukinumab, and ixekizumab in children with psoriasis.

SUBMITTER: Zheng YX

PROVIDER: S-EPMC9490006 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Biologics for psoriasis patients under 18 years of age: Real-world evidence from the Chinese psoriasis real world evidence research group.

Zheng Yu-Xin YX Ye Li-Ran LR Yan Bing-Xi BX Chen Si-Qi SQ Cai Sui-Qing SQ Man Xiao-Yong XY

Frontiers in medicine 20220907

<h4>Background</h4>Treatment for pediatric psoriasis is challenging because of the lack of real-world evidence, especially for biological therapies.<h4>Objectives</h4>This study evaluated the efficacy and safety of biologics in children with psoriasis based on real-world evidence.<h4>Methods</h4>Pediatric psoriasis patients aged <18 years who were treated with biologics in our hospital (2020-2022) were prospectively analyzed. Patients treated with adalimumab, secukinumab, or ixekizumab were foll ...[more]

PMID: 36160145

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Dataset Information

Biologics for psoriasis patients under 18 years of age: Real-world evidence from the Chinese psoriasis real world evidence research group.

Background

Objectives

Methods

Results

Conclusions

Publications

Biologics for psoriasis patients under 18 years of age: Real-world evidence from the Chinese psoriasis real world evidence research group.

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