Ontology highlight
ABSTRACT:
SUBMITTER: MacArthur MR
PROVIDER: S-EPMC9490641 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
MacArthur Michael R MR Mitchell Sarah J SJ Chadaideh Katia S KS Treviño-Villarreal J Humberto JH Jung Jonathan J Kalafut Krystle C KC Reynolds Justin S JS Mann Charlotte G CG Trocha Kaspar M KM Tao Ming M Aye Cho Tay-Zar TZ Koontanatechanon Anantawat A Yeliseyev Vladimir V Bry Lynn L Longchamp Alban A Ozaki C Keith CK Lewis Caroline A CA Carmody Rachel N RN Mitchell James R JR
Cell reports 20220801 7
Dietary protein restriction (PR) has rapid effects on metabolism including improved glucose and lipid homeostasis, via multiple mechanisms. Here, we investigate responses of fecal microbiome, hepatic transcriptome, and hepatic metabolome to six diets with protein from 18% to 0% of energy in mice. PR alters fecal microbial composition, but metabolic effects are not transferable via fecal transplantation. Hepatic transcriptome and metabolome are significantly altered in diets with lower than 10% e ...[more]