Ontology highlight
ABSTRACT:
SUBMITTER: Huang K
PROVIDER: S-EPMC9493395 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Huang Kuilong K Jia Zhihao Z Li Haoran H Peng Ying Y Chen Xiaochang X Luo Nanjian N Song Tongxing T Wang Yingqian Y Shi Xin'e X Kuang Shihuan S Yang Gongshe G
The Journal of biological chemistry 20220802 10
Family with sequence similarity 83 A (FAM83A) is a newly discovered proto-oncogene that has been shown to play key roles in various cancers. However, the function of FAM83A in other physiological processes is not well known. Here, we report a novel function of FAM83A in adipocyte differentiation. We used an adipocyte-targeting fusion oligopeptide (FITC-ATS-9R) to deliver a FAM83A-sgRNA/Cas9 plasmid to knockdown Fam83a (ATS/sg-FAM83A) in white adipose tissue in mice, which resulted in reduced whi ...[more]