Ontology highlight
ABSTRACT: Background
Serum neurofilament light (sNfL) chain is a promising biomarker reflecting neuro-axonal injury in multiple sclerosis (MS). However, the ability of sNfL to predict outcomes in real-world MS cohorts requires further validation.Objective
The aim of the study is to investigate the associations of sNfL concentration, magnetic resonance imaging (MRI) and retinal optical coherence tomography (OCT) markers with disease worsening in a longitudinal European multicentre MS cohort.Methods
MS patients (n = 309) were prospectively enrolled at four centres and re-examined after 2 years (n = 226). NfL concentration was measured by single molecule array assay in serum. The patients' phenotypes were thoroughly characterized with clinical examination, retinal OCT and MRI brain scans. The primary outcome was disease worsening at median 2-year follow-up.Results
Patients with high sNfL concentrations (⩾8 pg/mL) at baseline had increased risk of disease worsening at median 2-year follow-up (odds ratio (95% confidence interval) = 2.8 (1.5-5.3), p = 0.001). We found no significant associations of MRI or OCT measures at baseline with risk of disease worsening.Conclusion
Serum NfL concentration was the only factor associated with disease worsening, indicating that sNfL is a useful biomarker in MS that might be relevant in a clinical setting.
SUBMITTER: Brune S
PROVIDER: S-EPMC9493412 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Brune Synne S Høgestøl Einar A EA de Rodez Benavent Sigrid A SA Berg-Hansen Pål P Beyer Mona K MK Leikfoss Ingvild Sørum IS Bos Steffan D SD Sowa Piotr P Brunborg Cathrine C Andorra Magi M Pulido Valdeolivas Irene I Asseyer Susanna S Brandt Alexander A Chien Claudia C Scheel Michael M Blennow Kaj K Zetterberg Henrik H Kerlero de Rosbo Nicole N Paul Friedemann F Uccelli Antonio A Villoslada Pablo P Berge Tone T Harbo Hanne F HF
Multiple sclerosis (Houndmills, Basingstoke, England) 20220604 12
<h4>Background</h4>Serum neurofilament light (sNfL) chain is a promising biomarker reflecting neuro-axonal injury in multiple sclerosis (MS). However, the ability of sNfL to predict outcomes in real-world MS cohorts requires further validation.<h4>Objective</h4>The aim of the study is to investigate the associations of sNfL concentration, magnetic resonance imaging (MRI) and retinal optical coherence tomography (OCT) markers with disease worsening in a longitudinal European multicentre MS cohort ...[more]