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Lecithin-Polysaccharide Self-Assembled Microspheres for Resveratrol Delivery.

ABSTRACT: Poor water solubility and low chemical stability, seriously limit the efficient bioavailability of resveratrol. Here, we propose encapsulating resveratrol in lecithin-polysaccharide self-assembled microspheres (LPSM). An LPSM was designed with a lecithin core, and alginate-carboxymethyl chitosan biolayer shell. The LPSM had a spherical shape with 12.171 ± 0.960 μm of particle size and -30.86 ± 1.37 mV of zeta potential. The introduce of lecithin remarkably increased the encapsulation efficiency of resveratrol to 92.78 ± 0.82%. The LPSM elevated the antioxidant capacity and ultraviolet resistance of resveratrol. Moreover, LPSM inhibited release in a simulated gastric environment, promoted sustained release in simulated intestinal environment, and elevated the bioavailability of resveratrol during in vitro simulated digestion. Results indicate that LPSM is promising as a carrier for resveratrol delivery to enhance stability and bioaccessibility.

SUBMITTER: Wang L

PROVIDER: S-EPMC9495455 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Lecithin-Polysaccharide Self-Assembled Microspheres for Resveratrol Delivery.

Wang Lei L Lai Congting C Li Dong D Luo Zisheng Z Liu Lingling L Jiang Yunbin Y Li Li L

Antioxidants (Basel, Switzerland) 20220826 9

Poor water solubility and low chemical stability, seriously limit the efficient bioavailability of resveratrol. Here, we propose encapsulating resveratrol in lecithin-polysaccharide self-assembled microspheres (LPSM). An LPSM was designed with a lecithin core, and alginate-carboxymethyl chitosan biolayer shell. The LPSM had a spherical shape with 12.171 ± 0.960 μm of particle size and -30.86 ± 1.37 mV of zeta potential. The introduce of lecithin remarkably increased the encapsulation efficiency ...[more]

PMID: 36139740

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