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GS-2: A Novel Broad-Spectrum Agent for Environmental Microbial Control.

ABSTRACT: The environmental control of microbial pathogens currently relies on compounds that do not exert long-lasting activity on surfaces, are impaired by soil, and contribute to the growing problem of antimicrobial resistance. This study presents the scientific development and characterization of GS-2, a novel, water-soluble ammonium carboxylate salt of capric acid and L-arginine that demonstrates activity against a range of bacteria (particularly Gram-negative bacteria), fungi, and viruses. In real-world surface testing, GS-2 was more effective than a benzalkonium chloride disinfectant at reducing the bacterial load on common touch-point surfaces in a high-traffic building (average 1.6 vs. 32.6 CFUs recovered from surfaces 90 min after application, respectively). Toxicology testing in rats confirmed GS-2 ingredients were rapidly cleared and posed no toxicities to humans or animals. To enhance the time-kill against Gram-positive bacteria, GS-2 was compounded at a specific ratio with a naturally occurring monoterpenoid, thymol, to produce a water-based antimicrobial solution. This GS-2 with thymol formulation could generate a bactericidal effect after five minutes of exposure and a viricidal effect after 10 min of exposure. Further testing of the GS-2 and thymol combination on glass slides demonstrated that the compound retained bactericidal activity for up to 60 days. Based on these results, GS-2 and GS-2 with thymol represent a novel antimicrobial solution that may have significant utility in the long-term reduction of environmental microbial pathogens in a variety of settings.

SUBMITTER: Mayfosh AJ

PROVIDER: S-EPMC9496126 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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GS-2: A Novel Broad-Spectrum Agent for Environmental Microbial Control.

Mayfosh Alyce J AJ Day Zoe I ZI Unsworth Nathan B NB Liu Chun-Qiang CQ Gupta Ruchi R Haynes Soraya S Abraham Rebecca R Abraham Sam S Shaw Zo L ZL Walia Sumeet S Elbourne Aaron A Hulett Mark D MD Rau Thomas F TF

Biomolecules 20220913 9

The environmental control of microbial pathogens currently relies on compounds that do not exert long-lasting activity on surfaces, are impaired by soil, and contribute to the growing problem of antimicrobial resistance. This study presents the scientific development and characterization of GS-2, a novel, water-soluble ammonium carboxylate salt of capric acid and L-arginine that demonstrates activity against a range of bacteria (particularly Gram-negative bacteria), fungi, and viruses. In real-w ...[more]

PMID: 36139131

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GS-2: A Novel Broad-Spectrum Agent for Environmental Microbial Control.

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GS-2: A Novel Broad-Spectrum Agent for Environmental Microbial Control.

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