Proteomic, Metabolomic, and Lipidomic Analyses of Lung Tissue Exposed to Mustard Gas.
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ABSTRACT:
SUBMITTER: Dhummakupt E
PROVIDER: S-EPMC9501011 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Publications
Proteomic, Metabolomic, and Lipidomic Analyses of Lung Tissue Exposed to Mustard Gas.
Dhummakupt Elizabeth E Jenkins Conor C Rizzo Gabrielle G Melka Allison A Carmany Daniel D Prugh Amber A Horsmon Jennifer J Renner Julie J Angelini Daniel D
Metabolites 20220830 9
Sulfur mustard (HD) poses a serious threat due to its relatively simple production process. Exposure to HD in the short-term causes an inflammatory response, while long-term exposure results in DNA and RNA damage. Respiratory tract tissue models were exposed to relatively low concentrations of HD and collected at 3 and 24 h post exposure. Histology, cytokine ELISAs, and mass spectrometric-based analyses were performed. Histology and ELISA data confirmed previously seen lung damage and inflammato ...[more]
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