Ontology highlight
ABSTRACT:
SUBMITTER: Roger I
PROVIDER: S-EPMC9501359 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Roger Inés I Montero Paula P García Antonio A Milara Javier J Ribera Pilar P Pérez-Fidalgo Jose Alejandro JA Cortijo Julio J
Pharmaceuticals (Basel, Switzerland) 20220906 9
Delayed-type hypersensitivity (DTH) is caused by a broad number of drugs used in clinic, and antineoplastic drugs show an elevated proportion of DTH, which potentially affects the quality of life of patients. Despite the serious problem and the negative economic impact deriving from market withdrawal of such drugs and high hospitalization costs, nowadays, there are no standard validated methods in vitro or in vivo to evaluate the sensitizing potential of drugs in the preclinical phase. Enhanced ...[more]