Unknown

Dataset Information

0

Reversible Self-Assembled Monolayers with Tunable Surface Dynamics for Controlling Cell Adhesion Behavior.


ABSTRACT: Cells adhering onto surfaces sense and respond to chemical and physical surface features. The control over cell adhesion behavior influences cell migration, proliferation, and differentiation, which are important considerations in biomaterial design for cell culture, tissue engineering, and regenerative medicine. Here, we report on a supramolecular-based approach to prepare reversible self-assembled monolayers (rSAMs) with tunable lateral mobility and dynamic control over surface composition to regulate cell adhesion behavior. These layers were prepared by incubating oxoacid-terminated thiol SAMs on gold in a pH 8 HEPES buffer solution containing different mole fractions of ω-(ethylene glycol)2-4- and ω-(GRGDS)-, α-benzamidino bolaamphiphiles. Cell shape and morphology were influenced by the strength of the interactions between the amidine-functionalized amphiphiles and the oxoacid of the underlying SAMs. Dynamic control over surface composition, achieved by the addition of inert filler amphiphiles to the RGD-functionalized rSAMs, reversed the cell adhesion process. In summary, rSAMs featuring mobile bioactive ligands offer unique capabilities to influence and control cell adhesion behavior, suggesting a broad use in biomaterial design, tissue engineering, and regenerative medicine.

SUBMITTER: Yeung SY 

PROVIDER: S-EPMC9501787 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Reversible Self-Assembled Monolayers with Tunable Surface Dynamics for Controlling Cell Adhesion Behavior.

Yeung Sing Yee SY   Sergeeva Yulia Y   Pan Guoqing G   Mittler Silvia S   Ederth Thomas T   Dam Tommy T   Jönsson Peter P   El-Schich Zahra Z   Wingren Anette Gjörloff AG   Tillo Adam A   Hsiung Mattisson Sabrina S   Holmqvist Bo B   Stollenwerk Maria M MM   Sellergren Börje B  

ACS applied materials & interfaces 20220908 37


Cells adhering onto surfaces sense and respond to chemical and physical surface features. The control over cell adhesion behavior influences cell migration, proliferation, and differentiation, which are important considerations in biomaterial design for cell culture, tissue engineering, and regenerative medicine. Here, we report on a supramolecular-based approach to prepare reversible self-assembled monolayers (rSAMs) with tunable lateral mobility and dynamic control over surface composition to  ...[more]

Similar Datasets

| S-EPMC10811624 | biostudies-literature
| S-EPMC9043331 | biostudies-literature
| S-EPMC8262134 | biostudies-literature
| S-EPMC11533155 | biostudies-literature
| S-EPMC5704293 | biostudies-literature
| S-EPMC8456949 | biostudies-literature
| S-EPMC2787851 | biostudies-literature
| S-EPMC11795717 | biostudies-literature
| S-EPMC5477012 | biostudies-literature
| S-EPMC3374047 | biostudies-literature