Construction and consequences of directed mutations affecting the hemin receptor in pathogenic Corynebacterium species.
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ABSTRACT:
SUBMITTER: Schmitt MP
PROVIDER: S-EPMC95026 | biostudies-literature | 2001 Feb
REPOSITORIES: biostudies-literature
Publications
Construction and consequences of directed mutations affecting the hemin receptor in pathogenic Corynebacterium species.
Journal of bacteriology 20010201 4
Genes encoding an ATP-binding cassette transporter system involved in hemin iron utilization from Corynebacterium ulcerans were cloned and characterized. The genes are homologous to a hemin transport system previously identified in Corynebacterium diphtheriae. Disruption of the hmuT gene, which encodes the putative hemin receptor, resulted in greatly reduced ability of C. ulcerans to use hemin or hemoglobin as an iron source. Inactivation of hmuT in C. diphtheriae by site-specific recombination ...[more]
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