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The Emerging Role of Venetoclax-Based Treatments in Acute Lymphoblastic Leukemia.

ABSTRACT: Venetoclax, a B-cell lymphoma (BCL-2) inhibitor, in combination with hypomethylating agents has become the new standard of care in elderly and unfit patients with acute myeloid leukemia, with significantly improved overall survival and quality of life. Studies of venetoclax combined with high-dose chemotherapy are emerging with evidence of higher rates of molecular remission. Recently, a growing number of publications bring forth the use of venetoclax in patients with acute lymphoblastic leukemia (ALL). In the current review, we present the biological rationale of BCL-2 inhibition in ALL, how the interplay of BH3 proteins modulate the response and the current clinical experience with various combinations.

SUBMITTER: Aumann S

PROVIDER: S-EPMC9504828 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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The Emerging Role of Venetoclax-Based Treatments in Acute Lymphoblastic Leukemia.

Aumann Shlomzion S Shaulov Adir A Haran Arnon A Gross Even-Zohar Noa N Vainstein Vladimir V Nachmias Boaz B

International journal of molecular sciences 20220919 18

Venetoclax, a B-cell lymphoma (BCL-2) inhibitor, in combination with hypomethylating agents has become the new standard of care in elderly and unfit patients with acute myeloid leukemia, with significantly improved overall survival and quality of life. Studies of venetoclax combined with high-dose chemotherapy are emerging with evidence of higher rates of molecular remission. Recently, a growing number of publications bring forth the use of venetoclax in patients with acute lymphoblastic leukemi ...[more]

PMID: 36142863

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