Ontology highlight
ABSTRACT:
SUBMITTER: Krummnow A
PROVIDER: S-EPMC9505701 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Krummnow Adrian A Danzer Andreas A Voges Kristin K Dohrn Stefanie S Kyeremateng Samuel O SO Degenhardt Matthias M Sadowski Gabriele G
Pharmaceutics 20220908 9
In amorphous solid dispersions (ASDs), an active pharmaceutical ingredient (API) is dissolved on a molecular level in a polymeric matrix. The API is expected to be released from the ASD upon dissolution in aqueous media. However, a series of earlier works observed a drastic collapse of the API release for ASDs with high drug loads (DLs) compared to those with low DLs. This work provides a thermodynamic analysis of the release mechanism of ASDs composed of ritonavir (RIT) and poly(vinylpyrrolidon ...[more]