Dataset Information

Performance evaluation of the BC-720 auto hematology analyzer and establishment of the reference intervals of erythrocyte sedimentation rate in healthy adults.

ABSTRACT:

Background

Erythrocyte sedimentation rate (ESR) is a new reporting parameter of the BC-720 auto hematology analyzer; however, no biological reference interval for healthy adults has been established for this parameter.

Methods

Outpatients or hospitalized patients with ESR test orders were selected. The ESR was measured by the standard method of ESR (Westergren) recommended by the International Council for Standardization in Hematology (ICSH), the BC-720 hematology analyzer, and the LBY-XC40B auto ESR analyzer. The data were statistically analyzed and compared among different methods. The repeatability and carryover rate (CR) of the BC-720 were assessed in randomly selected samples for each range segment. Blood Samples from three hospitals in China were collected, and the reference interval of the BC-720 ESR was determined.

Results

The ESR results measured by the BC-720 correlated well with the Westergren method (r=0.957, y = 0.359 + 1.016x), and there was no significant difference between these two methods (P>0.05). The correlation between LBY-XC40B auto ESR analyzer and Westergren was y = 1 + 1.25x and r=0.856. The BC-720 ESR has good repeatability [standard deviation (SD) ≤1 mm/h, coefficient of variation (CV) ≤5%], and the CR was less than 1%. The 95th percentile of the biological reference interval for BC-720 ESR is 15 mm/h for men and 24 mm/h for women.

Conclusions

The Mindray BC-720 ESR showed high accuracy and good repeatability, which provided a faster, safer, and more reliable method to measure ESR. The reference intervals for BC-720 ESR could guide better clinical decisions for the laboratories utilizing this new method.

SUBMITTER: Shu G

PROVIDER: S-EPMC9511180 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

Performance evaluation of the BC-720 auto hematology analyzer and establishment of the reference intervals of erythrocyte sedimentation rate in healthy adults.

Shu Guofang G Ding Rui R Ding Rong R He Zhi Z Shen Yimin Y Liu Dongmei D Duan Zhaohui Z

Annals of translational medicine 20220901 17

<h4>Background</h4>Erythrocyte sedimentation rate (ESR) is a new reporting parameter of the BC-720 auto hematology analyzer; however, no biological reference interval for healthy adults has been established for this parameter.<h4>Methods</h4>Outpatients or hospitalized patients with ESR test orders were selected. The ESR was measured by the standard method of ESR (Westergren) recommended by the International Council for Standardization in Hematology (ICSH), the BC-720 hematology analyzer, and th ...[more]

PMID: 36172102

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Project description:BackgroundMindray's newly developed BC-7500 CRP auto hematology analyzers can simultaneously measure the routine blood and C-reactive protein (CRP) results, thereby significantly improving the efficiency and quality of clinical examination. This study was designed to evaluate the basic performance of the BC-7500 CRP as well as the performance characteristics of the new measurement mode combines routine blood and CRP.MethodsVenous whole blood samples with the anticoagulant ethylene diamine tetraacetic acid K2 (EDTA-K2) were collected at the Fujian Medical University Union Hospital according to the guidelines of the American Clinical Laboratory Standards Institute (CLSI) and International Standards Committee for Hematology (ISCH). We analyzed and evaluated the performance of blank counts, carryover contamination rate, precision, comparability, flagging capability, sample stability, and automatic micro-whole blood (MWB) mode analysis in the BC-7500 CRP hematology analyzer.ResultsAll parameters measured by the BC-7500 CRP showed good blank counts (CRP, 0.008-0.02 mg/L). The carryover contamination rates for each mode combination did not exceed 1%, it indicates a low carryover effect. The CRP showed high precision while the within-laboratory precision is 6.91% and 4.38% in two different levels. Relatively good correlation was found for the routine blood results between the BC-7500 CRP and Sysmex-XN (r=0.99), and CRP result between the BC-7500 CRP and IMMAGE 800 (r=0.99). The sensitivities of abnormal cell flagging for Blast, Immature Gran, and nucleated red blood cell (NRBC) were 93.9%, 91.6%, and 86.7%, while their specificities were 83.9%, 62.7%, and 97.5%. The test results of CRP at room temperature for 24 hours and refrigerated for 48 hours were -0.04% and -2.94%, which showed very stable changes. Also, the automatic micro-whole blood mode performed well (P=0.2014), which was very close to the test results of the automatic mixing test of peripheral blood and the manual mixing of open sampling.ConclusionsThe BC-7500 CRP analyzer provided reliable results on routine blood and CRP, which can meet the testing requirements of routine blood and CRP items in clinical whole blood samples and provide a guarantee for rapid and accurate laboratory diagnosis.

Dataset Information

Performance evaluation of the BC-720 auto hematology analyzer and establishment of the reference intervals of erythrocyte sedimentation rate in healthy adults.

Background

Methods

Results

Conclusions

Publications

Performance evaluation of the BC-720 auto hematology analyzer and establishment of the reference intervals of erythrocyte sedimentation rate in healthy adults.

Similar Datasets

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