Deleterious Mutations and the Rare Allele Burden on Rice Gene Expression.
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ABSTRACT:
SUBMITTER: Lye Z
PROVIDER: S-EPMC9512150 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
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Deleterious Mutations and the Rare Allele Burden on Rice Gene Expression.
Lye Zoe Z Choi Jae Young JY Purugganan Michael D MD
Molecular biology and evolution 20220901 9
Deleterious genetic variation is maintained in populations at low frequencies. Under a model of stabilizing selection, rare (and presumably deleterious) genetic variants are associated with increase or decrease in gene expression from some intermediate optimum. We investigate this phenomenon in a population of largely Oryza sativa ssp. indica rice landraces under normal unstressed wet and stressful drought field conditions. We include single nucleotide polymorphisms, insertion/deletion mutations ...[more]
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