Multi-functional BST2/tetherin against HIV-1, other viruses and LINE-1.
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ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC9513188 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Multi-functional BST2/tetherin against HIV-1, other viruses and LINE-1.
Zhao Yifei Y Zhao Ke K Wang Shaohua S Du Juan J
Frontiers in cellular and infection microbiology 20220913
Bone marrow stromal cell antigen 2 (BST2), also known as CD317, HM1.24, or tetherin, is a type II transmembrane glycoprotein. Its expression is induced by IFN-I, and it initiates host immune responses by directly trapping enveloped HIV-1 particles onto the cell surface. This antagonistic mechanism toward the virus is attributable to the unique structure of BST2. In addition to its antiviral activity, BST2 restricts retrotransposon LINE-1 through a distinct mechanism. As counteractive measures, d ...[more]
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