Ontology highlight
ABSTRACT:
SUBMITTER: Wallace CH
PROVIDER: S-EPMC9515385 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Wallace Charles H CH Oliveros Giovanni G Serrano Peter A PA Rockwell Patricia P Xie Lei L Figueiredo-Pereira Maria M
Life science alliance 20220927 12
We investigated the relevance of the prostaglandin D2 pathway in Alzheimer's disease, because prostaglandin D2 is a major prostaglandin in the brain. Thus, its contribution to Alzheimer's disease merits attention, given the known impact of the prostaglandin E2 pathway in Alzheimer's disease. We used the TgF344-AD transgenic rat model because it exhibits age-dependent and progressive Alzheimer's disease pathology. Prostaglandin D2 levels in hippocampi of TgF344-AD and wild-type littermates were s ...[more]