Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity.
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ABSTRACT:
SUBMITTER: Backes IM
PROVIDER: S-EPMC9516843 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
Maternally transferred mAbs protect neonatal mice from HSV-induced mortality and morbidity.
Backes Iara M IM Byrd Brook K BK Slein Matthew D MD Patel Chaya D CD Taylor Sean A SA Garland Callaghan R CR MacDonald Scott W SW Balazs Alejandro B AB Davis Scott C SC Ackerman Margaret E ME Leib David A DA
The Journal of experimental medicine 20220926 12
Neonatal herpes simplex virus (nHSV) infections often result in significant mortality and neurological morbidity despite antiviral drug therapy. Maternally transferred herpes simplex virus (HSV)-specific antibodies reduce the risk of clinically overt nHSV, but this observation has not been translationally applied. Using a neonatal mouse model, we tested the hypothesis that passive transfer of HSV-specific human mAbs can prevent mortality and morbidity associated with nHSV. The mAbs were expresse ...[more]
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