Ontology highlight
ABSTRACT:
SUBMITTER: Mattinzoli D
PROVIDER: S-EPMC9523396 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Mattinzoli Deborah D Cacioppo Michele M Ikehata Masami M Armelloni Silvia S Alfieri Carlo Maria CM Castellano Giuseppe G Barilani Mario M Arcudi Francesca F Messa Piergiorgio P Prato Maurizio M
Materials today. Bio 20220901
Irinotecan (CTP-11) is one of the standard therapies for colorectal cancer (CRC). CTP-11 is enzymatically converted to the hydrophobic 7-ethyl-10-hydroxycamptothecin (SN38), a one hundred-fold more active metabolite. Conjugation of hydrophobic anticancer drugs to nanomaterials is a strategy to improve their solubility, efficacy, and selectivity. Carbon dots (CDs) have garnered interest for their small sizes (<10 nm), low toxicity, high water solubility, and bright fluorescence. This paper descr ...[more]