Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC9525646 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Li Ying Y Wu Meng M Zhang Lili L Wan Li L Li Hexin H Zhang Lanxin L Sun Gaoyuan G Huang Wei W Zhang Junhua J Su Fei F Tang Min M Xiao Fei F
Cell death discovery 20220930 1
The restoration of the normal function of the tumour suppressors, such as p53, is an important strategy in tumour therapeutics. Nonsense-mediated mRNA decay (NMD) inhibition by NMD inhibitor (NMDi) upregulates functional p53 isoforms, p53β and p53γ, and activates the p53 pathway. XR-2, a novel mouse double minute 2 homolog (MDM2) inhibitor, can disrupt the interaction between p53 and MDM2, thus decreasing the MDM2-mediated degradation of p53 and increasing the p53 protein levels. However, the co ...[more]