Ontology highlight
ABSTRACT:
SUBMITTER: Bolivar-Wagers S
PROVIDER: S-EPMC9536261 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Bolivar-Wagers Sara S Loschi Michael L ML Jin Sujeong S Thangavelu Govindarajan G Larson Jemma H JH McDonald-Hyman Cameron S CS Aguilar Ethan G EG Saha Asim A Koehn Brent H BH Hefazi Mehrdad M Osborn Mark J MJ Jensen Michael C MC Wagner John E JE Pennell Christopher A CA Blazar Bruce R BR
JCI insight 20220908 17
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) efficacy is complicated by graft-versus-host disease (GVHD), a leading cause of morbidity and mortality. Regulatory T cells (Tregs) have shown efficacy in preventing GVHD. However, high Treg doses are often required, necessitating substantial ex vivo or in vivo expansion that may diminish suppressor function. To enhance in vivo suppressor function, murine Tregs were transduced to express an anti-human CD19 chimeric antigen receptor ( ...[more]