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An optimized platform for efficient siRNA delivery into human NK cells.


ABSTRACT: The molecular networks that regulate natural killer (NK) cell functions are not completely understood. Here, we present a workflow for efficient delivery of siRNA into human NK cells without compromising viability. This methodology represents a promising approach for rapidly interrogating gene functions in primary human NK cells.

SUBMITTER: Palacios D 

PROVIDER: S-EPMC9541389 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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An optimized platform for efficient siRNA delivery into human NK cells.

Palacios Daniel D   Momayyezi Pouria P   Huhn Oisín O   Ask Eivind Heggernes EH   Dunst Josefine J   Malmberg Karl-Johan KJ   Hammer Quirin Q  

European journal of immunology 20220422 7


The molecular networks that regulate natural killer (NK) cell functions are not completely understood. Here, we present a workflow for efficient delivery of siRNA into human NK cells without compromising viability. This methodology represents a promising approach for rapidly interrogating gene functions in primary human NK cells. ...[more]

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