Dataset Information

Virtual epileptic patient brain modeling: Relationships with seizure onset and surgical outcome.

ABSTRACT:

Objective

The virtual epileptic patient (VEP) is a large-scale brain modeling method based on virtual brain technology, using stereoelectroencephalography (SEEG), anatomical data (magnetic resonance imaging [MRI] and connectivity), and a computational neuronal model to provide computer simulations of a patient's seizures. VEP has potential interest in the presurgical evaluation of drug-resistant epilepsy by identifying regions most likely to generate seizures. We aimed to assess the performance of the VEP approach in estimating the epileptogenic zone and in predicting surgical outcome.

Methods

VEP modeling was retrospectively applied in a cohort of 53 patients with pharmacoresistant epilepsy and available SEEG, T1-weighted MRI, and diffusion-weighted MRI. Precision recall was used to compare the regions identified as epileptogenic by VEP (EZ_VEP ) to the epileptogenic zone defined by clinical analysis incorporating the Epileptogenicity Index (EI) method (EZ_C ). In 28 operated patients, we compared the VEP results and clinical analysis with surgical outcome.

Results

VEP showed a precision of 64% and a recall of 44% for EZ_VEP detection compared to EZ_C . There was a better concordance of VEP predictions with clinical results, with higher precision (77%) in seizure-free compared to non-seizure-free patients. Although the completeness of resection was significantly correlated with surgical outcome for both EZ_C and EZ_VEP , there was a significantly higher number of regions defined as epileptogenic exclusively by VEP that remained nonresected in non-seizure-free patients.

Significance

VEP is the first computational model that estimates the extent and organization of the epileptogenic zone network. It is characterized by good precision in detecting epileptogenic regions as defined by a combination of visual analysis and EI. The potential impact of VEP on improving surgical prognosis remains to be exploited. Analysis of factors limiting the performance of the actual model is crucial for its further development.

SUBMITTER: Makhalova J

PROVIDER: S-EPMC9543509 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Publications

Virtual epileptic patient brain modeling: Relationships with seizure onset and surgical outcome.

Makhalova Julia J Medina Villalon Samuel S Wang Huifang H Giusiano Bernard B Woodman Marmaduke M Bénar Christian C Guye Maxime M Jirsa Viktor V Bartolomei Fabrice F

Epilepsia 20220606 8

<h4>Objective</h4>The virtual epileptic patient (VEP) is a large-scale brain modeling method based on virtual brain technology, using stereoelectroencephalography (SEEG), anatomical data (magnetic resonance imaging [MRI] and connectivity), and a computational neuronal model to provide computer simulations of a patient's seizures. VEP has potential interest in the presurgical evaluation of drug-resistant epilepsy by identifying regions most likely to generate seizures. We aimed to assess the perf ...[more]

PMID: 35604575

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Project description:BackgroundEpilepsy surgery is a potentially curative treatment option for pharmacoresistent patients. If non-invasive methods alone do not allow to delineate the epileptogenic brain areas the surgical candidates undergo long-term monitoring with intracranial EEG. Visual EEG analysis is then used to identify the seizure onset zone for targeted resection as a standard procedure.MethodsDespite of its great potential to assess the epileptogenicty of brain tissue, quantitative EEG analysis has not yet found its way into routine clinical practice. To demonstrate that quantitative EEG may yield clinically highly relevant information we retrospectively investigated how post-operative seizure control is associated with four selected EEG measures evaluated in the resected brain tissue and the seizure onset zone. Importantly, the exact spatial location of the intracranial electrodes was determined by coregistration of pre-operative MRI and post-implantation CT and coregistration with post-resection MRI was used to delineate the extent of tissue resection. Using data-driven thresholding, quantitative EEG results were separated into normally contributing and salient channels.ResultsIn patients with favorable post-surgical seizure control a significantly larger fraction of salient channels in three of the four quantitative EEG measures was resected than in patients with unfavorable outcome in terms of seizure control (median over the whole peri-ictal recordings). The same statistics revealed no association with post-operative seizure control when EEG channels contributing to the seizure onset zone were studied.ConclusionsWe conclude that quantitative EEG measures provide clinically relevant and objective markers of target tissue, which may be used to optimize epilepsy surgery. The finding that differentiation between favorable and unfavorable outcome was better for the fraction of salient values in the resected brain tissue than in the seizure onset zone is consistent with growing evidence that spatially extended networks might be more relevant for seizure generation, evolution and termination than a single highly localized brain region (i.e. a "focus") where seizures start.

Dataset Information

Virtual epileptic patient brain modeling: Relationships with seizure onset and surgical outcome.

Objective

Methods

Results

Significance

Publications

Virtual epileptic patient brain modeling: Relationships with seizure onset and surgical outcome.

Similar Datasets

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