Dataset Information

Associations between pre- and postnatal antibiotic exposures and early allergic outcomes: A population-based birth cohort study.

ABSTRACT:

Background

Early life antibiotic treatment is one likely exposure influencing allergy risk. The objective was to investigate associations between pre- and postnatal antibiotic exposures and the development of allergic manifestations until age 18 months.

Methods

We included 1387 mother-child dyads from the prospective, population-based NorthPop birth cohort study. Data on antibiotic exposures in pregnancy and childhood were collected by web-based questionnaires. Until the child turned 18 months old, parents (n = 1219) reported symptoms of wheeze, eczema, and physician-diagnosed asthma; parents (n = 1025) reported physician-diagnosed food allergy. At age 18 months, serum immunoglobulin E levels to inhalant (Phadiatop) and food (Food mix fx5) allergens were determined. Associations were estimated using bivariable and multivariable logistic regressions.

Results

Prenatal antibiotic exposure was positively associated with food sensitization in the crude (OR 1.82, 95% CI 1.01-3.26) but not in the adjusted analyses (aOR 1.58, 0.82-3.05). A borderline significant association was found between prenatal exposure and wheeze (aOR 1.56, 0.95-2.57). Postnatal antibiotics were positively associated with wheeze (aOR 2.14, 1.47-3.11), asthma (aOR 2.35, 1.32-4.19), and eczema (aOR 1.49, 1.07-2.06). Postnatal antibiotics were negatively associated with food sensitization (aOR 0.46, 95% CI 0.25-0.83) but not with food allergy nor sensitization to inhalants.

Conclusion

Pre- and postnatal antibiotic exposure demonstrated positive associations with allergic manifestations and the former also with food sensitization. In contrast, there was a negative association between postnatal antibiotics and food sensitization. Food sensitization is often transient but may precede respiratory allergies. Future studies should investigate the relationship between antibiotic exposure and food sensitization later in childhood.

SUBMITTER: Kelderer F

PROVIDER: S-EPMC9544930 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

Associations between pre- and postnatal antibiotic exposures and early allergic outcomes: A population-based birth cohort study.

Kelderer Fanny F Mogren Ingrid I Eriksson Catharina C Silfverdal Sven-Arne SA Domellöf Magnus M West Christina E CE

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20220901 9

<h4>Background</h4>Early life antibiotic treatment is one likely exposure influencing allergy risk. The objective was to investigate associations between pre- and postnatal antibiotic exposures and the development of allergic manifestations until age 18 months.<h4>Methods</h4>We included 1387 mother-child dyads from the prospective, population-based NorthPop birth cohort study. Data on antibiotic exposures in pregnancy and childhood were collected by web-based questionnaires. Until the child tur ...[more]

PMID: 36156813

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Dataset Information

Associations between pre- and postnatal antibiotic exposures and early allergic outcomes: A population-based birth cohort study.

Background

Methods

Results

Conclusion

Publications

Associations between pre- and postnatal antibiotic exposures and early allergic outcomes: A population-based birth cohort study.

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