Dataset Information

SARS-CoV-2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals: A serial cross-sectional study.

ABSTRACT:

Background

The COVID-19 situation in Brazil is complex due to large differences in the shape and size of regional epidemics. Understanding these patterns is crucial to understand future outbreaks of SARS-CoV-2 or other respiratory pathogens in the country.

Methods

We tested 97,950 blood donation samples for IgG antibodies from March 2020 to March 2021 in 8 of Brazil's most populous cities. Residential postal codes were used to obtain representative samples. Weekly age- and sex-specific seroprevalence were estimated by correcting the crude seroprevalence by test sensitivity, specificity, and antibody waning.

Results

The inferred attack rate of SARS-CoV-2 in December 2020, before the Gamma variant of concern (VOC) was dominant, ranged from 19.3% (95% credible interval [CrI] 17.5-21.2%) in Curitiba to 75.0% (95% CrI 70.8-80.3%) in Manaus. Seroprevalence was consistently smaller in women and donors older than 55 years. The age-specific infection fatality rate (IFR) differed between cities and consistently increased with age. The infection hospitalisation rate increased significantly during the Gamma-dominated second wave in Manaus, suggesting increased morbidity of the Gamma VOC compared to previous variants circulating in Manaus. The higher disease penetrance associated with the health system's collapse increased the overall IFR by a minimum factor of 2.91 (95% CrI 2.43-3.53).

Conclusions

These results highlight the utility of blood donor serosurveillance to track epidemic maturity and demonstrate demographic and spatial heterogeneity in SARS-CoV-2 spread.

Funding

This work was supported by Itaú Unibanco 'Todos pela Saude' program; FAPESP (grants 18/14389-0, 2019/21585-0); Wellcome Trust and Royal Society Sir Henry Dale Fellowship 204311/Z/16/Z; the Gates Foundation (INV- 034540 and INV-034652); REDS-IV-P (grant HHSN268201100007I); the UK Medical Research Council (MR/S0195/1, MR/V038109/1); CAPES; CNPq (304714/2018-6); Fundação Faculdade de Medicina; Programa Inova Fiocruz-CE/Funcap - Edital 01/2020 Number: FIO-0167-00065.01.00/20 SPU N°06531047/2020; JBS - Fazer o bem faz bem.

SUBMITTER: Prete CA

PROVIDER: S-EPMC9545556 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

SARS-CoV-2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals: A serial cross-sectional study.

Prete Carlos A CA Buss Lewis F LF Whittaker Charles C Salomon Tassila T Oikawa Marcio K MK Pereira Rafael H M RHM Moura Isabel C G ICG Delerino Lucas L Barral-Netto Manoel M Tavares Natalia M NM Franca Rafael F O RFO Boaventura Viviane S VS Miyajima Fabio F Mendrone-Junior Alfredo A de Almeida-Neto Cesar C Salles Nanci A NA Ferreira Suzete C SC Fladzinski Karine A KA de Souza Luana M LM Schier Luciane K LK Inoue Patricia M PM Xabregas Lilyane A LA Crispim Myuki A E MAE Fraiji Nelson N Araujo Fernando L V FLV Carlos Luciana M B LMB Pessoa Veridiana V Ribeiro Maisa A MA de Souza Rosenvaldo E RE da Silva Sônia M N SMN Cavalcante Anna F AF Valença Maria I B MIB da Silva Maria V MV Lopes Esther E Filho Luiz A LA Mateos Sheila O G SOG Nunes Gabrielle T GT Silva-Junior Alexander L AL Busch Michael P MP Castro Marcia C MC Dye Christopher C Ratmann Oliver O Faria Nuno R NR Nascimento Vítor H VH Sabino Ester C EC

eLife 20220922

<h4>Background</h4>The COVID-19 situation in Brazil is complex due to large differences in the shape and size of regional epidemics. Understanding these patterns is crucial to understand future outbreaks of SARS-CoV-2 or other respiratory pathogens in the country.<h4>Methods</h4>We tested 97,950 blood donation samples for IgG antibodies from March 2020 to March 2021 in 8 of Brazil's most populous cities. Residential postal codes were used to obtain representative samples. Weekly age- and sex-spe ...[more]

PMID: 36135358

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Dataset Information

SARS-CoV-2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals: A serial cross-sectional study.

Background

Methods

Results

Conclusions

Funding

Publications

SARS-CoV-2 antibody dynamics in blood donors and COVID-19 epidemiology in eight Brazilian state capitals: A serial cross-sectional study.

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