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The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis.

ABSTRACT: Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism. HNF4α-related diseases include non-alcoholic fatty liver disease (NAFLD), obesity, hypertension, hyperlipidemia, metabolic syndrome and diabetes mellitus. Recently, HNF4α has been emerging as a key player in a variety of cancers. In this review, we summarized the role and mechanism of HNF4α in different types of cancers, especially in liver and colorectal cancer, aiming to provide additional guidance for intervention of these diseases.

SUBMITTER: Sang L

PROVIDER: S-EPMC9554155 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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The role of hepatocyte nuclear factor 4α (HNF4α) in tumorigenesis.

Sang Lei L Wang Xingshun X Bai Weiyu W Shen Junling J Zeng Yong Y Sun Jianwei J

Frontiers in oncology 20220928

Hepatocyte Nuclear Factor 4 Alpha (HNF4α) is a master transcription factor mainly expressed in the liver, kidney, intestine and endocrine pancreas. It regulates multiple target genes involved in embryonic development and metabolism. HNF4α-related diseases include non-alcoholic fatty liver disease (NAFLD), obesity, hypertension, hyperlipidemia, metabolic syndrome and diabetes mellitus. Recently, HNF4α has been emerging as a key player in a variety of cancers. In this review, we summarized the rol ...[more]

PMID: 36249028

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