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Direct observational evidence of an oceanic dual kinetic energy cascade and its seasonality.

ABSTRACT: The ocean's turbulent energy cycle has a paradox; large-scale eddies under the control of Earth's rotation transfer kinetic energy (KE) to larger scales via an inverse cascade, while a transfer to smaller scales is needed for dissipation. It has been hypothesized, using simulations, that fronts, waves, and other turbulent structures can produce a forward cascade of KE toward dissipation scales. However, this forward cascade and its coexistence with the inverse cascade have never been observed. Here, we present the first evidence of a dual KE cascade in the ocean by analyzing in situ velocity measurements from surface drifters. Our results show that KE is injected at two dominant scales and transferred to both large and small scales, with the downscale flux dominating at scales smaller than ∼1 to 10 km. The cascade rates are modulated seasonally, with stronger KE injection and downscale transfer during winter.

SUBMITTER: Balwada D

PROVIDER: S-EPMC9555769 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Direct observational evidence of an oceanic dual kinetic energy cascade and its seasonality.

Balwada Dhruv D Xie Jin-Han JH Marino Raffaele R Feraco Fabio F

Science advances 20221012 41

The ocean's turbulent energy cycle has a paradox; large-scale eddies under the control of Earth's rotation transfer kinetic energy (KE) to larger scales via an inverse cascade, while a transfer to smaller scales is needed for dissipation. It has been hypothesized, using simulations, that fronts, waves, and other turbulent structures can produce a forward cascade of KE toward dissipation scales. However, this forward cascade and its coexistence with the inverse cascade have never been observed. H ...[more]

PMID: 36223461

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Project description:ObjectivesTo demonstrate the feasibility of an automated, non-invasive approach to estimate bone marrow (BM) infiltration of multiple myeloma (MM) by dual-energy computed tomography (DECT) after virtual non-calcium (VNCa) post-processing.MethodsIndividuals with MM and monoclonal gammopathy of unknown significance (MGUS) with concurrent DECT and BM biopsy between May 2018 and July 2020 were included in this retrospective observational study. Two pathologists and three radiologists reported BM infiltration and presence of osteolytic bone lesions, respectively. Bone mineral density (BMD) was quantified CT-based by a CE-certified software. Automated spine segmentation was implemented by a pre-trained convolutional neural network. The non-fatty portion of BM was defined as voxels > 0 HU in VNCa. For statistical assessment, multivariate regression and receiver operating characteristic (ROC) were conducted.ResultsThirty-five patients (mean age 65 ± 12 years; 18 female) were evaluated. The non-fatty portion of BM significantly predicted BM infiltration after adjusting for the covariable BMD (p = 0.007, r = 0.46). A non-fatty portion of BM > 0.93% could anticipate osteolytic lesions and the clinical diagnosis of MM with an area under the ROC curve of 0.70 [0.49-0.90] and 0.71 [0.54-0.89], respectively. Our approach identified MM-patients without osteolytic lesions on conventional CT with a sensitivity and specificity of 0.63 and 0.71, respectively.ConclusionsAutomated, AI-supported attenuation assessment of the spine in DECT VNCa is feasible to predict BM infiltration in MM. Further, the proposed method might allow for pre-selecting patients with higher pre-test probability of osteolytic bone lesions and support the clinical diagnosis of MM without pathognomonic lesions on conventional CT.Key points• The retrospective study provides an automated approach for quantification of the non-fatty portion of bone marrow, based on AI-supported spine segmentation and virtual non-calcium dual-energy CT data. • An increasing non-fatty portion of bone marrow is associated with a higher infiltration determined by invasive biopsy after adjusting for bone mineral density as a control variable (p = 0.007, r = 0.46). • The non-fatty portion of bone marrow might support the clinical diagnosis of multiple myeloma when conventional CT images are negative (sensitivity 0.63, specificity 0.71).

Dataset Information

Direct observational evidence of an oceanic dual kinetic energy cascade and its seasonality.

Publications

Direct observational evidence of an oceanic dual kinetic energy cascade and its seasonality.

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