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Molecular analysis of OXA-48-producing Escherichia coli in Switzerland from 2019 to 2020.

ABSTRACT: OXA-48-type ß-lactamases are the most prevalent carbapenemase-type in Enterobacterales in Switzerland, predominantly found in Escherichia coli and Klebsiella pneumoniae. Bacteria-producing OXA-48-type enzymes are endemic in some parts of the world, including Europe and North Africa, and are a frequent cause of nosocomial infections. Despite the emergence of numerous OXA-48-type variants, the original variant, OXA-48, remains the most prevalent in E. coli. This study describes the epidemiology of OXA-48-producing E. coli isolates submitted to the Swiss National Reference Center for Emerging Antibiotic Resistance (NARA) between January 2019 and December 2020.

SUBMITTER: Findlay J

PROVIDER: S-EPMC9556411 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Molecular analysis of OXA-48-producing Escherichia coli in Switzerland from 2019 to 2020.

Findlay Jacqueline J Perreten Vincent V Poirel Laurent L Nordmann Patrice P

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20220914 11

OXA-48-type ß-lactamases are the most prevalent carbapenemase-type in Enterobacterales in Switzerland, predominantly found in Escherichia coli and Klebsiella pneumoniae. Bacteria-producing OXA-48-type enzymes are endemic in some parts of the world, including Europe and North Africa, and are a frequent cause of nosocomial infections. Despite the emergence of numerous OXA-48-type variants, the original variant, OXA-48, remains the most prevalent in E. coli. This study describes the epidemiology of ...[more]

PMID: 36103096

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