Dataset Information

Geraniol Treatment for Irritable Bowel Syndrome: A Double-Blind Randomized Clinical Trial.

ABSTRACT: Geraniol is an acyclic monoterpene alcohol with well-known anti-inflammatory and antimicrobial properties which has shown eubiotic activity towards gut microbiota (GM) in patients with irritable bowel syndrome (IBS).

Methods

Fifty-six IBS patients diagnosed according to Rome III criteria were enrolled in an interventional, prospective, multicentric, randomized, double-blinded, placebo-controlled trial. In the treatment arm, patients received a low-absorbable geraniol food supplement (LAGS) once daily for four weeks.

Results

Patients treated with LAGS showed a significant reduction in their IBS symptoms severity score (IBS-SSS) compared to the placebo (195 vs. 265, p = 0.001). The rate of responders according to IBS-SSS (reduction ≥ 50 points) was significantly higher in the geraniol vs placebo group (52.0% vs. 16.7%, p = 0.009) mainly due to the IBS mixed subtype. There were notable differences in the microbiota composition after geraniol administration, particularly a significant decrease in a genus of Ruminococcaceae, Oscillospira (p = 0.01), a decreasing trend for the Erysipelotrichaceae and Clostridiaceae families (p = 0.1), and an increasing trend for other Ruminococcaceae taxa, specifically Faecalibacterium (p = 0.09). The main circulating proinflammatory cytokines showed no differences between placebo and geraniol arms.

Conclusion

LAGS was effective in treating overall IBS symptoms, together with an improvement in the gut microbiota profile, especially for the IBS mixed subtype.

SUBMITTER: Ricci C

PROVIDER: S-EPMC9571173 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Publications

Geraniol Treatment for Irritable Bowel Syndrome: A Double-Blind Randomized Clinical Trial.

Ricci Chiara C Rizzello Fernando F Valerii Maria Chiara MC Spisni Enzo E Gionchetti Paolo P Turroni Silvia S Candela Marco M D'Amico Federica F Spigarelli Renato R Bellocchio Irene I Marasco Giovanni G Barbara Giovanni G

Nutrients 20221010 19

Geraniol is an acyclic monoterpene alcohol with well-known anti-inflammatory and antimicrobial properties which has shown eubiotic activity towards gut microbiota (GM) in patients with irritable bowel syndrome (IBS).<h4>Methods</h4>Fifty-six IBS patients diagnosed according to Rome III criteria were enrolled in an interventional, prospective, multicentric, randomized, double-blinded, placebo-controlled trial. In the treatment arm, patients received a low-absorbable geraniol food supplement (LAGS ...[more]

PMID: 36235860

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Dataset Information

Geraniol Treatment for Irritable Bowel Syndrome: A Double-Blind Randomized Clinical Trial.

Methods

Results

Conclusion

Publications

Geraniol Treatment for Irritable Bowel Syndrome: A Double-Blind Randomized Clinical Trial.

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