Dataset Information

The Association of Blood Urea Nitrogen to Creatinine Ratio and the Prognosis of Critically Ill Patients with Cerebral Infarction: A Cohort Study.

ABSTRACT:

Background

To evaluate the association between blood urea nitrogen (BUN) to creatinine (Cr) (BUN/Cr) ratio and the in-hospital mortality of critically ill patients with cerebral infarction in intensive care unit (ICU).

Methods

In this cohort study, the data of 3059 participants with cerebral infarction were collected from the Medical Information Mart for Intensive Care (MIMIC)-III and the MIMIC-IV database. After propensity score matching (PSM) on age and gender, 2085 people were involved in and divided into the alive group (n = 1390) and the dead group (n = 695) based on the results of follow-up. Multivariate logistic analyses were applied to identify the confounders and the association between BUN/Cr and mortality of cerebral infarction.

Results

The median follow-up time was 10.5 days. Among 2778 participants, 695 were dead at the end of follow-up. Univariate analysis revealed that BUN/Cr [risk ratio (RR) = 1.01, 95% confidence interval (CI): 1.01-1.02] might be associated with the in-hospital mortality of cerebral infarction patients. After adjusting for respiratory failure, malignant cancer, anticoagulation, liver disease, white blood cell (WBC), red cell distribution width (RDW), glucose, bicarbonate, and temperature, BUN/Cr had week correlation with the increased risk of in-hospital mortality of cerebral infarction patients (RR = 1.01, 95% CI: 1.01-1.02).

Conclusion

This study evaluated the association between BUN/Cr and the in-hospital mortality of cerebral infarction patients in ICU and found that BUN/Cr had weak correlation with the increased risk of in-hospital mortality of patients with cerebral infarction in ICU especially in males and those with respiratory failure, malignant cancer, and without liver disease, as well as those receiving anticoagulation.

SUBMITTER: Chen T

PROVIDER: S-EPMC9576422 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

The Association of Blood Urea Nitrogen to Creatinine Ratio and the Prognosis of Critically Ill Patients with Cerebral Infarction: A Cohort Study.

Chen Ting T Li Ai-Ping AP Gong Qi Q Zhou Lin L Zhao Yi-Xuan YX Zhou Zhi-Wen ZW Zhou Wen-Sheng WS

Mediators of inflammation 20221010

<h4>Background</h4>To evaluate the association between blood urea nitrogen (BUN) to creatinine (Cr) (BUN/Cr) ratio and the in-hospital mortality of critically ill patients with cerebral infarction in intensive care unit (ICU).<h4>Methods</h4>In this cohort study, the data of 3059 participants with cerebral infarction were collected from the Medical Information Mart for Intensive Care (MIMIC)-III and the MIMIC-IV database. After propensity score matching (PSM) on age and gender, 2085 people were ...[more]

PMID: 36262546

Similar Datasets

Project description:ObjectiveChronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and death. The blood urea nitrogen-to-creatinine ratio (BCR) is recognized as a crucial marker to assess renal function and cardiovascular risk. Nevertheless, the effects of BCR on COPD patients suffering comorbid congestive heart failure (CHF) is not clarified. This study aims to elucidate the association between BCR and CHF risk in the COPD population.MethodsData from COPD patients meeting the eligibility criteria were from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. The cumulative incidence curve was utilized for examining the link of BCR to CHF. Kaplan-Meier (KM) analysis was carried out for evaluating the relation of BCR to in-hospital mortality(IHM). Multivariable Cox regression assisted in assessing the correlation of BCR with CHF risk. Restricted cubic splines (RCS) were leveraged for unraveling the association of BCR (as a continuous variable) with CHF.ResultsOur study included 2,840 COPD patients in the intensive care unit for the first time, with hospital stays exceeding 24 h. The incidence of CHF was 57.18% among these patients. Cumulative incidence curve analysis demonstrated a notably increased CHF incidence in patients having higher BCR (18.889 < BCR ≤ 92.5) in contrast to those with lower BCR (2.877 ≤ BCR ≤ 18.889) (p < 0.0001). KM survival analysis indicated a markedly elevated IHM risk in patients with higher BCR in comparison to those with lower BCR (p < 0.0001). Multivariable Cox regression and RCS analysis further confirmed that higher BCR was linked to a risen likelihood of CHF [hazard ratio (HR) = 1.28, 95% confidence interval (CI, 1.15-1.44), p < 0.001]. Subgroup analysis revealed a higher risk of CHF [HR = 1.41, 95% CI (1.13-1.76), p = 0.002] in patients with diabetes than those without [HR = 1.24, 95% CI (1.08-1.41), p = 0.002].ConclusionElevated BCR is an independent risk factor for CHF in critically ill COPD individuals and strongly related to a risen risk of CHF. The findings prove BCR as a reliable clinical predictor, facilitating risk stratification and personalized treatment for COPD patients with comorbid CHF.

Project description:The present study aimed to determine the association between the blood urea nitrogen (BUN) and creatinine (Cr) ratio and in-hospital mortality in patients with acute myocardial infarction (AMI). The present retrospective cohort study included adult patients (≥18 years of age) who were admitted to the intensive care unit (ICU) with a primary diagnosis of AMI. Medical records were obtained from the electronic ICU collaborative research database, which includes data from throughout continental USA. Data included demographic characteristics, vital signs, laboratory tests and comorbidities. The clinical endpoint was in-hospital mortality. The Cox proportional hazards model was used to evaluate the prognostic values of the basic BUN/Cr ratio and the Kaplan-Meier method was used to plot survival curves. Subgroup analyses were performed to measure mortality across various subgroups. In total, 5,965 eligible patients were included. In the Cox regression analysis, after being adjusted for age, sex, ethnicity and other confounding factors, the BUN/Cr ratio was found to be a significant risk predictor of in-hospital mortality. There was a non-linear relationship between the BUN/Cr ratio and in-hospital mortality after adjusting for potential confounders. A two-piecewise regression model was used to obtain a threshold inflection point value of 18. Furthermore, after adjusting for additional confounding factors (age, sex, ethnicity, BMI, heart rate, oxygen saturation, platelets, total protein, AMI category, heart failure, history of diabetes, history of hypertension, percutaneous coronary intervention, and administration of norepinephrine, dopamine and epinephrine), the BUN/Cr ratio remained a significant predictor of in-hospital mortality (third vs. first tertile: Hazard ratio, 1.50; 95% CI, 1.08-2.09; P<0.05). The Kaplan-Meier curve for tertiles of the BUN/Cr ratio indicated that in-hospital mortality rates were highest when the BUN/Cr ratio was ≥18.34 after adjustment for age, sex and ethnicity (P<0.05). The present findings demonstrated that a higher BUN/Cr ratio was associated with an increased risk of in-hospital mortality in patients with non-ST-segment elevation myocardial infarction. These results support a revision of how the prognosis of patients with AMI is predicted.

Dataset Information

The Association of Blood Urea Nitrogen to Creatinine Ratio and the Prognosis of Critically Ill Patients with Cerebral Infarction: A Cohort Study.

Background

Methods

Results

Conclusion

Publications

The Association of Blood Urea Nitrogen to Creatinine Ratio and the Prognosis of Critically Ill Patients with Cerebral Infarction: A Cohort Study.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets