Dataset Information

Rates of Asymptomatic COVID-19 Infection and Associated Factors in Olmsted County, Minnesota, in the Prevaccination Era.

ABSTRACT:

Objective

To estimate rates and identify factors associated with asymptomatic COVID-19 in the population of Olmsted County during the prevaccination era.

Patients and methods

We screened first responders (n=191) and Olmsted County employees (n=564) for antibodies to SARS-CoV-2 from November 1, 2020 to February 28, 2021 to estimate seroprevalence and asymptomatic infection. Second, we retrieved all polymerase chain reaction (PCR)-confirmed COVID-19 diagnoses in Olmsted County from March 2020 through January 2021, abstracted symptom information, estimated rates of asymptomatic infection and examined related factors.

Results

Twenty (10.5%; 95% CI, 6.9%-15.6%) first responders and 38 (6.7%; 95% CI, 5.0%-9.1%) county employees had positive antibodies; an additional 5 (2.6%) and 10 (1.8%) had prior positive PCR tests per self-report or medical record, but no antibodies detected. Of persons with symptom information, 4 of 20 (20%; 95% CI, 3.0%-37.0%) first responders and 10 of 39 (26%; 95% CI, 12.6%-40.0%) county employees were asymptomatic. Of 6020 positive PCR tests in Olmsted County with symptom information between March 1, 2020, and January 31, 2021, 6% (n=385; 95% CI, 5.8%-7.1%) were asymptomatic. Factors associated with asymptomatic disease included age (0-18 years [odds ratio {OR}, 2.3; 95% CI, 1.7-3.1] and >65 years [OR, 1.40; 95% CI, 1.0-2.0] compared with ages 19-44 years), body mass index (overweight [OR, 0.58; 95% CI, 0.44-0.77] or obese [OR, 0.48; 95% CI, 0.57-0.62] compared with normal or underweight) and tests after November 20, 2020 ([OR, 1.35; 95% CI, 1.13-1.71] compared with prior dates).

Conclusion

Asymptomatic rates in Olmsted County before COVID-19 vaccine rollout ranged from 6% to 25%, and younger age, normal weight, and later tests dates were associated with asymptomatic infection.

SUBMITTER: Vachon CM

PROVIDER: S-EPMC9578336 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

Rates of Asymptomatic COVID-19 Infection and Associated Factors in Olmsted County, Minnesota, in the Prevaccination Era.

Vachon Celine M CM Norman Aaron D AD Prasad Kavita K Jensen Dan D Schaeferle Gavin M GM Vierling Kristy L KL Sherden Meaghan M Majerus Michelle R MR Bews Katherine A KA Heinzen Ethan P EP Hebl Amy A Yost Kathleen J KJ Kennedy Richard B RB Theel Elitza S ES Ghosh Aditya A Fries Meghan M Wi Chung-Il CI Juhn Young J YJ Sampathkumar Priya P Morice William G WG Rocca Walter A WA Tande Aaron J AJ Cerhan James R JR Limper Andrew H AH Ting Henry H HH Farrugia Gianrico G Carter Rickey E RE Finney Rutten Lila J LJ Jacobson Robert M RM St Sauver Jennifer J

Mayo Clinic proceedings. Innovations, quality & outcomes 20221018 6

<h4>Objective</h4>To estimate rates and identify factors associated with asymptomatic COVID-19 in the population of Olmsted County during the prevaccination era.<h4>Patients and methods</h4>We screened first responders (n=191) and Olmsted County employees (n=564) for antibodies to SARS-CoV-2 from November 1, 2020 to February 28, 2021 to estimate seroprevalence and asymptomatic infection. Second, we retrieved all polymerase chain reaction (PCR)-confirmed COVID-19 diagnoses in Olmsted County from ...[more]

PMID: 36277251

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Dataset Information

Rates of Asymptomatic COVID-19 Infection and Associated Factors in Olmsted County, Minnesota, in the Prevaccination Era.

Objective

Patients and methods

Results

Conclusion

Publications

Rates of Asymptomatic COVID-19 Infection and Associated Factors in Olmsted County, Minnesota, in the Prevaccination Era.

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