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Adaptable Bed for Curved-Layered Fused Deposition Modeling of Nonplanar Structures: A Proof of Concept.

ABSTRACT: Curved-layered fused deposition modeling demands a curved mandrel for each of the designs to fabricate. This results in more fabrication time and material used. To overcome this, an adaptable pin-base mandrel is presented. The fabrication of curved structures with such mandrel uses the extruder as a pushing tool, pushing each of the pins to the depths required for each surface. After the base surface is formed, the conventional process of curved fused deposition modeling (FDM) is used. Several lattice shell structures composed of nonplanar layers were fabricated on FDM mandrels and the adaptable pin-bed proposed here. The comparison of the manufacturing results showed that the adaptable base allows the successful fabrication of the samples. The solution exposed here represents a proof of concept to validate the idea. The adaptable base presented in this study is unique and it brings advantages to the fabrication of curved-layered structures.

SUBMITTER: Ramirez-Gutierrez DL

PROVIDER: S-EPMC9586230 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Adaptable Bed for Curved-Layered Fused Deposition Modeling of Nonplanar Structures: A Proof of Concept.

Ramírez-Gutiérrez Diana L DL Cuan-Urquizo Enrique E Gómez-Espinosa Alfonso A

3D printing and additive manufacturing 20200812 4

Curved-layered fused deposition modeling demands a curved mandrel for each of the designs to fabricate. This results in more fabrication time and material used. To overcome this, an adaptable pin-base mandrel is presented. The fabrication of curved structures with such mandrel uses the extruder as a pushing tool, pushing each of the pins to the depths required for each surface. After the base surface is formed, the conventional process of curved fused deposition modeling (FDM) is used. Several l ...[more]

PMID: 36654928

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Project description:ObjectiveCurrent prevention and/or treatment options for respiratory syncytial virus (RSV) infections are limited as no vaccine is available. Prophylaxis with palivizumab is very expensive and requires multiple intramuscular injections over the RSV season. Here we present proof-of-concept data using nebulized palivizumab delivery as a promising new approach for the prevention or treatment of severe RSV infections, documenting both aerosol characteristics and pulmonary deposition patterns in the lungs of lambs.DesignProspective animal study.SettingBiosecurity Control Level 2-designated large animal research facility at the Murdoch Children's Research Institute, Melbourne, Australia.SubjectsFour weaned Border-Leicester/Suffolk lambs at 5 months of age.InterventionsFour lambs were administered aerosolized palivizumab conjugated to Tc-99m, under gaseous anesthesia, using either the commercially available AeroNeb Go® or the investigational HYDRA device, placed in-line with the inspiratory limb of a breathing circuit. Lambs were scanned in a single-photon emission computed tomography (SPECT/CT) scanner in the supine position during the administration procedure.Measurements and main resultsBoth the HYDRA and AeroNeb Go® produced palivizumab aerosols in the 1-5 µm range with similar median (geometric standard deviation and range) aerosol droplet diameters for the HYDRA device (1.84 ± 1.40 μm, range = 0.54-5.41μm) and the AeroNeb Go® (3.07 ± 1.56 μm, range = 0.86-10 μm). Aerosolized palivizumab was delivered to the lungs at 88.79-94.13% of the total aerosolized amount for all lambs, with a small proportion localized to either the trachea or stomach. No difference between devices were found. Pulmonary deposition ranged from 6.57 to 9.25% of the total dose of palivizumab loaded in the devices, mostly in the central right lung.ConclusionsAerosolized palivizumab deposition patterns were similar in all lambs, suggesting a promising approach in the control of severe RSV lung infections.

Project description:BackgroundHospital bed management is an important resource allocation task in hospital management, but currently, it is a challenging task. However, acquiring an optimal solution is also difficult because intraorganizational information asymmetry exists. Signaling, as defined in the fields of economics, can be used to mitigate this problem.ObjectiveWe aimed to develop an assignment process that is based on a token economy as signaling intermediary.MethodsWe implemented a game-like simulation, representing token economy-based bed assignments, in which 3 players act as ward managers of 3 inpatient wards (1 each). As a preliminary evaluation, we recruited 9 nurse managers to play and then participate in a survey about qualitative perceptions for current and proposed methods (7-point Likert scale). We also asked them about preferred rewards for collected tokens. In addition, we quantitatively recorded participant pricing behavior.ResultsParticipants scored the token economy-method positively in staff satisfaction (3.89 points vs 2.67 points) and patient safety (4.38 points vs 3.50 points) compared to the current method, but they scored the proposed method negatively for managerial rivalry, staff employee development, and benefit for patients. The majority of participants (7 out of 9) listed human resources as the preferred reward for tokens. There were slight associations between workload information and pricing.ConclusionsSurvey results indicate that the proposed method can improve staff satisfaction and patient safety by increasing the decision-making autonomy of staff but may also increase managerial rivalry, as expected from existing criticism for decentralized decision-making. Participant behavior indicated that token-based pricing can act as a signaling intermediary. Given responses related to rewards, a token system that is designed to incorporate human resource allocation is a promising method. Based on aforementioned discussion, we concluded that a token economy-based bed allocation system has the potential to be an optimal method by mitigating information asymmetry.

Dataset Information

Adaptable Bed for Curved-Layered Fused Deposition Modeling of Nonplanar Structures: A Proof of Concept.

Publications

Adaptable Bed for Curved-Layered Fused Deposition Modeling of Nonplanar Structures: A Proof of Concept.

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