Ontology highlight
ABSTRACT:
SUBMITTER: Davis DA
PROVIDER: S-EPMC9598996 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Davis David A DA Bulut Haydar H Shrestha Prabha P Mitsuya Hiroaki H Yarchoan Robert R
Antioxidants (Basel, Switzerland) 20221018 10
Most viruses encode their own proteases to carry out viral maturation and these often require dimerization for activity. Studies on human immunodeficiency virus type 1 (HIV-1), type 2 (HIV-2) and human T-cell leukemia virus (HTLV-1) proteases have shown that the activity of these proteases can be reversibly regulated by cysteine (Cys) glutathionylation and/or methionine oxidation (for HIV-2). These modifications lead to inhibition of protease dimerization and therefore loss of activity. These ch ...[more]