Dataset Information

Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.

ABSTRACT: Prior criteria for organ dysfunction in critically ill children were based mainly on expert opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) expert panel to summarize data characterizing single and multiple organ dysfunction and to derive contemporary criteria for pediatric organ dysfunction. The panel was composed of 88 members representing 47 institutions and 7 countries. We conducted systematic reviews of the literature to derive evidence-based criteria for single organ dysfunction for neurologic, cardiovascular, respiratory, gastrointestinal, acute liver, renal, hematologic, coagulation, endocrine, endothelial, and immune system dysfunction. We searched PubMed and Embase from January 1992 to January 2020. Study identification was accomplished using a combination of medical subject headings terms and keywords related to concepts of pediatric organ dysfunction. Electronic searches were performed by medical librarians. Studies were eligible for inclusion if the authors reported original data collected in critically ill children; evaluated performance characteristics of scoring tools or clinical assessments for organ dysfunction; and assessed a patient-centered, clinically meaningful outcome. Data were abstracted from each included study into an electronic data extraction form. Risk of bias was assessed using the Quality in Prognosis Studies tool. Consensus was achieved for a final set of 43 criteria for pediatric organ dysfunction through iterative voting and discussion. Although the PODIUM criteria for organ dysfunction were limited by available evidence and will require validation, they provide a contemporary foundation for researchers to identify and study single and multiple organ dysfunction in critically ill children.

SUBMITTER: Bembea MM

PROVIDER: S-EPMC9599725 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.

Bembea Melania M MM Agus Michael M Akcan-Arikan Ayse A Alexander Peta P Basu Rajit R Bennett Tellen D TD Bohn Desmond D Brandão Leonardo R LR Brown Ann-Marie AM Carcillo Joseph A JA Checchia Paul P Cholette Jill J Cheifetz Ira M IM Cornell Timothy T Doctor Allan A Eckerle Michelle M Erickson Simon S Farris Reid W D RWD Faustino E Vincent S EVS Fitzgerald Julie C JC Fuhrman Dana Y DY Giuliano John S JS Guilliams Kristin K Gaies Michael M Gorga Stephen M SM Hall Mark M Hanson Sheila J SJ Hartman Mary M Hassinger Amanda B AB Irving Sharon Y SY Jeffries Howard H Jouvet Philippe P Kannan Sujatha S Karam Oliver O Khemani Robinder G RG Kissoon Niranjan N Lacroix Jacques J Laussen Peter P Leclerc Francis F Lee Jan Hau JH Leteurtre Stephane S Lobner Katie K McKiernan Patrick J PJ Menon Kusum K Monagle Paul P Muszynski Jennifer A JA Odetola Folafoluwa F Parker Robert R Pathan Nazima N Pathan Nazima N Pierce Richard W RW Pineda Jose J Prince Jose M JM Robinson Karen A KA Rowan Courtney M CM Ryerson Lindsay M LM Sanchez-Pinto L Nelson LN Schlapbach Luregn J LJ Selewski David T DT Shekerdemian Lara S LS Simon Dennis D Smith Lincoln S LS Squires James E JE Squires Robert H RH Sutherland Scott M SM Ouellette Yves Y Spaeder Michael C MC Srinivasan Vijay V Steiner Marie E ME Tasker Robert C RC Thiagarajan Ravi R Thomas Neal N Tissieres Pierre P Traube Chani C Tucci Marisa M Typpo Katri V KV Wainwright Mark S MS Ward Shan L SL Watson R Scott RS Weiss Scott S Whitney Jane J Willson Doug D Wynn James L JL Yehya Nadir N Zimmerman Jerry J JJ

Pediatrics 20220101 1 Suppl 1

Prior criteria for organ dysfunction in critically ill children were based mainly on expert opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) expert panel to summarize data characterizing single and multiple organ dysfunction and to derive contemporary criteria for pediatric organ dysfunction. The panel was composed of 88 members representing 47 institutions and 7 countries. We conducted systematic reviews of the literature to derive evidence-based criteria ...[more]

PMID: 34970673

Similar Datasets

Project description:ContextCardiovascular dysfunction is associated with poor outcomes in critically ill children.ObjectiveWe aim to derive an evidence-informed, consensus-based definition of cardiovascular dysfunction in critically ill children.Data sourcesElectronic searches of PubMed and Embase were conducted from January 1992 to January 2020 using medical subject heading terms and text words to define concepts of cardiovascular dysfunction, pediatric critical illness, and outcomes of interest.Study selectionStudies were included if they evaluated critically ill children with cardiovascular dysfunction and assessment and/or scoring tools to screen for cardiovascular dysfunction and assessed mortality, functional status, organ-specific, or other patient-centered outcomes. Studies of adults, premature infants (≤36 weeks gestational age), animals, reviews and/or commentaries, case series (sample size ≤10), and non-English-language studies were excluded. Studies of children with cyanotic congenital heart disease or cardiovascular dysfunction after cardiopulmonary bypass were excluded.Data extractionData were abstracted from each eligible study into a standard data extraction form, along with risk-of-bias assessment by a task force member.ResultsCardiovascular dysfunction was defined by 9 elements, including 4 which indicate severe cardiovascular dysfunction. Cardiopulmonary arrest (>5 minutes) or mechanical circulatory support independently define severe cardiovascular dysfunction, whereas tachycardia, hypotension, vasoactive-inotropic score, lactate, troponin I, central venous oxygen saturation, and echocardiographic estimation of left ventricular ejection fraction were included in any combination. There was expert agreement (>80%) on the definition.LimitationsAll included studies were observational and many were retrospective.ConclusionsThe Pediatric Organ Dysfunction Information Update Mandate panel propose this evidence-informed definition of cardiovascular dysfunction.

Dataset Information

Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.

Publications

Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets