Dataset Information

Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy.

ABSTRACT:

Background

This study investigated the prognostic value of axillary lymph node (ALN) heterogeneity texture features through ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) in patients with locally advanced breast cancer (LABC).

Methods

We retrospectively analyzed 158 LABC patients with FDG-avid, pathology-proven, metastatic ALN who underwent neoadjuvant chemotherapy (NAC) and curative surgery. Tumor and ALN texture parameters were extracted from pretreatment ¹⁸F-FDG PET/CT using Chang-Gung Image Texture Analysis software. The least absolute shrinkage and selection operator regression was performed to select the most significant predictive texture parameters. The predictive impact of texture parameters was evaluated for both progression-free survival and pathologic NAC response.

Results

The median follow-up period of 36.8 months and progression of disease (PD) was observed in 36 patients. In the univariate analysis, ALN textures (minimum standardized uptake value (SUV) (p = 0.026), SUV skewness (p = 0.038), SUV bias-corrected Kurtosis (p = 0.034), total lesion glycolysis (p = 0.011)), tumor textures (low-intensity size zone emphasis (p = 0.045), minimum SUV (p = 0.047), and homogeneity (p = 0.041)) were significant texture predictors. On the Cox regression analysis, ALN SUV skewness was an independent texture predictor of PD (p = 0.016, hazard ratio 2.3, 95% confidence interval 1.16-4.58).

Conclusions

ALN texture feature from pretreatment ¹⁸F-FDG PET/CT is useful for the prediction of LABC progression.

SUBMITTER: Hwang JP

PROVIDER: S-EPMC9600297 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Publications

Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy.

Hwang Jae Pil JP Choi Joon Young JY Choi Joon Ho JH Cho Young Seok YS Hur Sung Mo SM Kim Zisun Z Lim Cheol Wan CW Seo Seongho S Moon Ji Eun JE Woo Sang-Keun SK Park Jung Mi JM

Diagnostics (Basel, Switzerland) 20220922 10

<h4>Background</h4>This study investigated the prognostic value of axillary lymph node (ALN) heterogeneity texture features through <sup>18</sup>F-fluorodeoxyglucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) in patients with locally advanced breast cancer (LABC).<h4>Methods</h4>We retrospectively analyzed 158 LABC patients with FDG-avid, pathology-proven, metastatic ALN who underwent neoadjuvant chemotherapy (NAC) and curative surgery. Tumor and ALN texture par ...[more]

PMID: 36291974

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Dataset Information

Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy.

Background

Methods

Results

Conclusions

Publications

Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy.

Background

Methods

Results

Conclusions

Publications

Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Prognostic Value of Axillary Lymph Node Texture Parameters Measured by Pretreatment ¹⁸F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Locally Advanced Breast Cancer with Neoadjuvant Chemotherapy.