Ontology highlight
ABSTRACT:
SUBMITTER: Fan C
PROVIDER: S-EPMC9606073 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Fan Chengcheng C Cohen Alexander A AA Park Miso M Hung Alfur Fu-Hsin AF Keeffe Jennifer R JR Gnanapragasam Priyanthi N P PNP Lee Yu E YE Gao Han H Kakutani Leesa M LM Wu Ziyan Z Kleanthous Harry H Malecek Kathryn E KE Williams John C JC Bjorkman Pamela J PJ
Immunity 20221027 12
Increased immune evasion by SARS-CoV-2 variants of concern highlights the need for new therapeutic neutralizing antibodies. Immunization with nanoparticles co-displaying spike receptor-binding domains (RBDs) from eight sarbecoviruses (mosaic-8 RBD-nanoparticles) efficiently elicits cross-reactive polyclonal antibodies against conserved sarbecovirus RBD epitopes. Here, we identified monoclonal antibodies (mAbs) capable of cross-reactive binding and neutralization of animal sarbecoviruses and SARS ...[more]