Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women.
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ABSTRACT:
SUBMITTER: Peduzzi G
PROVIDER: S-EPMC9613634 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Publications
Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women.
Peduzzi Giulia G Archibugi Livia L Katzke Verena V Gentiluomo Manuel M Capurso Gabriele G Milanetto Anna Caterina AC Gazouli Maria M Goetz Mara M Brenner Hermann H Vermeulen Roel C H RCH Talar-Wojnarowska Renata R Vanella Giuseppe G Tavano Francesca F Lucchesi Maurizio M Mohelnikova-Duchonova Beatrice B Chen Xuechen X Kiudelis Vytautas V Hegyi Péter P Oliverius Martin M Stocker Hannah H Stornello Caterina C Vodickova Ludmila L Souček Pavel P Neoptolemos John P JP Testoni Sabrina Gloria Giulia SGG Morelli Luca L Lawlor Rita T RT Basso Daniela D Izbicki Jakob R JR Ermini Stefano S Kupcinskas Juozas J Pezzilli Raffaele R Boggi Ugo U van Laarhoven Hanneke W M HWM Szentesi Andrea A Erőss Bálint B Capretti Giovanni G Schöttker Ben B Skieceviciene Jurgita J Aoki Mateus Nóbrega MN van Eijck Casper H J CHJ Cavestro Giulia Martina GM Canzian Federico F Campa Daniele D
Scientific reports 20221027 1
The incidence of pancreatic ductal adenocarcinoma (PDAC) is different among males and females. This disparity cannot be fully explained by the difference in terms of exposure to known risk factors; therefore, the lower incidence in women could be attributed to sex-specific hormones. A two-phase association study was conducted in 12,387 female subjects (5436 PDAC cases and 6951 controls) to assess the effect on risk of developing PDAC of single nucleotide polymorphisms (SNPs) in 208 genes involve ...[more]
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