Dataset Information

Integrative analyses of genes about venous thromboembolism: An umbrella review of systematic reviews and meta-analyses.

ABSTRACT:

Background

In recent years, many studies have found possible links between gene polymorphisms and venous thromboembolism (VTE). By identifying genetic risk factors before facing environmental risk factors such as surgical interventions and COVID-19 vaccination, we could rapidly respond to the risk of VTE. The aim of this study was to perform an umbrella review of genetic variants related to VTE. Integrative gene analysis of VTE was performed to identify critical genetic variations.

Methods

This study conducted an umbrella review of systematic reviews and meta-analyses. All included studies were selected from the PubMed/MEDLINE database. To select eligible studies, the following variables were extracted: first author name; effect size of each study genetic variant; year of publication; the number of studies included in each article; ethnicity, sample size, P values, and heterogeneity estimates. To assess cumulative evidence in genetic epidemiology about effects of gene polymorphisms on VTE, Human Genome Epidemiology Network's Venice criteria were used. Methodological quality assessment was conducted with JBI Critical Appraisal Checklist for Systematic Reviews and Research Syntheses.

Results

Genes provided in the present study with genetic variants associated with VTE were FVL (G1691A), Prothrombin (G20210A), MTHFR (C677T, A1298C), PAI-1 (4G/5G), factor VII activating protease (1601G > A), and endothelial protein C receptor (g.6936A_G, c.4600A_G). Among them, variants in FVL, Prothrombin, MTHFR, and PAI-1 showed high significance. Particularly, variants in Prothrombin (G20210A), MTHFR (C677T), and PAI-1 (4G/5G) had more than 2 types of model significance.

Conclusion

The present study performed a systematic review of genetic variants associated with VTE. Our results could lead to a more comprehensive understanding of VTE etiology. These results could give a strategy of prediagnosis about evaluating individual risks of VTE who might be exposed to environmental risk factors.

SUBMITTER: Lee S

PROVIDER: S-EPMC9622592 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Publications

Integrative analyses of genes about venous thromboembolism: An umbrella review of systematic reviews and meta-analyses.

Lee Sangyeob S Lee Chang Han CH Seo Min Seok MS Yoo Jun-Il JI

Medicine 20221001 43

<h4>Background</h4>In recent years, many studies have found possible links between gene polymorphisms and venous thromboembolism (VTE). By identifying genetic risk factors before facing environmental risk factors such as surgical interventions and COVID-19 vaccination, we could rapidly respond to the risk of VTE. The aim of this study was to perform an umbrella review of genetic variants related to VTE. Integrative gene analysis of VTE was performed to identify critical genetic variations.<h4>Me ...[more]

PMID: 36316870

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Dataset Information

Integrative analyses of genes about venous thromboembolism: An umbrella review of systematic reviews and meta-analyses.

Background

Methods

Results

Conclusion

Publications

Integrative analyses of genes about venous thromboembolism: An umbrella review of systematic reviews and meta-analyses.

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